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KMID : 0361120080220010066
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Korean Journal of Transplantation
2008 Volume.22 No. 1 p.66 ~ p.69
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The Impact of Elderly Donor in Renal Transplantation
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Park Pil-Kyung
Kwon Oh-Jung
Kang Chong-Myung
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Abstract
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Purpose: Kidney transplantation from elderly donors is controversial because of decline of received renal function and increased risk of perioperative complication.
Methods: We retrospectively reviewed the records of the 676 patients from 1985 to 2006 in our center. 42 (6.2%) donors were ≥60 years old, and constitue the group 1, and 634 donors (93.8%) were ＜60 years old (group 2). We analysis graft survival, preoperative and postoperative creatinine, creatinine clearance, acute rejection rate, infection rate, delayed graft fucntion rate, HLA matching between groups.
Results: The average donor age in group 1 is 62.8 yr (60∼73) and 39.3 yr (16∼59) in group 2. Graft survival rate at 1, 5 and 10 years were 92%, 71%, 56% in group 1 vs 92%, 77%, 62% in group 2 (P=0.0831). There was no difference of graft survival between groups. In preoperative serum creatinine or postoperative days 3, 30 creatinine there was not difference between groups. Infection rate was 9.5% (4 patients) in group 1 vs. 7.3% (46 patients) in group 2. Acute rejection rate was 28.6% (12 patients) vs. 30.9% (196 patients). Delayed graft function (DGF) rate was 7.1% (3 patients) vs. 9.0% (57 patients). HLA-AB matching was 1.86 vs. 1.78 and HLA-DR matching was 1.12 vs. 1.06. All were not significantly different between groups. But the elderly donor group has a lower creatinine clearance at postoperative 3, 30 days (P=0.0422, 0.0231).
Conclusion: The short and long-term survival of kidney transplantation from elderly donors (≥60) are similar to younger donors (＜60). We suggest that use of elderly donors may help to expand the donor pool in kidney transplantation.
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KEYWORD
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Kidney transplantation, Elderly donor, Graft survival rate
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